CHEM503 Medicinal Chemistry

Updated: 05 December 2018
Credit Points 6
Offering
Responsible Campus Teaching Period Mode of Study
Armidale Trimester 1 Online
Armidale Trimester 1 On Campus
Intensive School(s)

Intensive schools are for students enrolled in Online Mode only, unless specified in the notes.

Start Finish Attendance Notes
02 May 2019 05 May 2019 Mandatory The intensive school is mandatory for online students only. Students must attend the Mandatory Intensive School which is held in Armidale.
Supervised Exam There is a supervised exam at the end of the teaching period in which you are enrolled. The paper-based exam will be held at an established exam venue, and coordinated by UNE Exams Unit.
Pre-requisites candidature in a postgraduate award
Co-requisites None
Restrictions CHEM303 or CHEM303A or CHEM403 or PHAR370
Notes None
Combined Units CHEM303 - Medicinal Chemistry
CHEM403 - Medicinal Chemistry
Coordinator(s) Ben Greatrex (ben.greatrex@une.edu.au)
Unit Description

This unit deals with drugs used in medicine, their mode of action and modern methods used for their discovery and development. It provides a chemical understanding of the role of metals in enzymes, drugs and diagnostic agents. It also deals with the metabolism of endogenous and exogenous organic drugs, the role of metabolism in toxicity and the effect of metabolism on pharmacokinetics. The unit will cover quantitative methods for determining activity (QSAR) and pharmacokinetic properties (QSPR). The practical part of the unit will teach methods for the synthesis of common functional groups as well as C-C and C-N bond forming reactions and methods for the isolation of bioactive compounds.

Recommended Material
Optional

Text(s):

Note: Recommended material is held in the University Library - purchase is optional

An Introduction to Medicinal Chemistry

ISBN: 9780198749691
Patrick, G., Oxford University Press 6th ed. 2017

Note: The 5th edition is also acceptable.

Text refers to: Trimester 1, On Campus and Online

Referenced Material
Optional

Text(s):

Note: Reference material is held in the University Library - purchase is optional

Metals in Medicine

ISBN: 9780470681978
Dabrowiak, J.C., Wiley 2009

Note: An eBook version is available through the Dixson Library.

Text refers to: Trimester 1, On Campus and Online

Disclaimer Unit information may be subject to change prior to commencement of the teaching period.
Assessment
Must
Complete
Title Exam Length Weight Mode No. Words
Compulsory Assessment 01 10%
Assessment Notes

Problem-based assignment requiring short answers and/or calculations. It is mandatory to pass this component in order to pass the unit.

Relates to Learning Outcomes (LO)

LO: 1, 2, 3, 4

Compulsory Assessment 02 10%
Assessment Notes

Problem-based assignment requiring short answers and/or calculations. It is mandatory to pass this component in order to pass the unit.

Relates to Learning Outcomes (LO)

LO: 1, 2, 3, 4

Compulsory Assessment 03 10%
Assessment Notes

Problem-based assignment requiring short answers and/or calculations. It is mandatory to pass this component in order to pass the unit.

Relates to Learning Outcomes (LO)

LO: 1, 2, 3, 4

Compulsory Assessment 04 30%
Assessment Notes

Seven practical assessment tasks. Students must submit all practical reports and gain an overall pass in the practical component in order to pass this unit.

Relates to Learning Outcomes (LO)

LO: 4, 5, 6

Compulsory Final Examination 2 hrs 15 mins 40%
Assessment Notes

It is mandatory to pass the final examination in order to pass this unit.

Relates to Learning Outcomes (LO)

LO: 1, 2, 3, 4, 6


Learning Outcomes (LO) Upon completion of this unit, students will be able to:
  1. understand in depth the interplay of structure, property and function of selected biologically important molecules and critically apply this advanced and integrated knowledge to solve problems in medicinal chemistry;
  2. devise routes to selected classes of complex molecules and critically analyse, reflect on and synthesise complex information from resources such as scifinder scholar to access appropriate scientific literature to refine designs;
  3. apply an advanced and integrated knowledge of inorganic chemistry to the understanding of complex structure and function relationships of metal containing drugs and enzymes;
  4. research and apply established theories to predict the pharmacokinetics of drugs in the body using quantitative structure property relationships and derive relationships relating structure and bioactivity;
  5. apply knowledge and expert skills to demonstrate common procedures such as reductive amination, acylation, crystallisation and chromatography to synthesise bioactive compounds as well as autonomously performing risk assessments and expert judgement and responsibility to ensure a safe working environment; and
  6. write comprehensive descriptions of experimental procedures for specialist chemists, and non-specialists, and effectively communicate ideas using established scientific language.